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Assessment of the Antiurolithiatic and Antioxidant Properties of Ficus pseudopalma Blanco Leaves (Moraceae)

Christine Joy H. Acosta, Allan Patrick H. Macabeo, Librado A. Santiago

Abstract


The present study investigates the antiurolithiatic and antioxidant potential of Ficus pseudopalma Blanco. The crude
dichloromethane (DCM) leaf extract was fractioned by silica gel column chromatography. Ethyl acetate fraction showed an IC50
of 0.2586 mg/mL against ·OH radical and 5.289 mg/mL against H202. The crude DCM extract was assessed for antiurolithiatic
property on ethylene‐glycol induced male Sprague‐Dawley rats. It was evaluated in preventive and therapeutic regimen. Fortytwo
rats were used with 6 rats per group. Preventive groups (Group 3 & 4) received induction with simultaneous treatment of
extract from Day 1‐28. Therapeutic groups (Group 5‐7) received induction on Day 1, co‐administration of extract started on
Day 15. The experimental groups were as follows: 1 – Vehicle, 2 – Induction control, 3 – 1000 mg/kg, 4 – 500 mg/kg, 5 – 1000
mg/kg, 6 – 500 mg/kg, and 7 – 10 mg/kg lupeol. The induction of ethylene glycol resulted to significant increase in
Malondialdehyde (MDA) levels, serum creatinine, urine oxalate and kidney calcium content (all p values are <0.05), consistent
with the histopathologic scoring of the kidney tissues wherein induction control group had the most number of crystal
deposits. However, treatment of F. pseudopalma crude DCM extract in both preventive and therapeutic design as well as lupeol
significantly decreased all the parameters (all p values are <0.05). Therapeutic dose of 1000 mg/kg F. pseudopalma crude DCM
extract was comparable to the effect of lupeol in significantly decreasing serum creatinine (p=0.998) and urine oxalate levels
(p=0.158). The present study established the antioxidant and antiurolithiatic potential of the plant.

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