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Anti-Fertility Activity of Butea Monosperma Linn in Albino Rats

Satyam Udiwal, Neetesh Kumar Jain, Swapnil Goyal

Abstract


In recent years, there has been a considerable interest in plants with possible antifertility effect. Only a few plants, reported to possess antifertility activity, have reached the stage of scientific clinical evaluation. In the present study, anti-fertility activity of Butea monosperma Linn. were characterized using different methods. Qualitative phytochemical screening of all the extracts was also conducted using qualitative tests to identify presence of alkaloids, phenolic compounds, tannins, flavonoids, saponins, glycosides, carbohydrates, proteins in the extracts. In vivo antiovulatory activity and in vitro spermicidal activity were also performed for pharmacological evaluation. The physical parameters such as total ash value, methanolic soluble extractive value, water soluble extractive value and loss on drying were found to be 12.67%, 18.54%, 9.59% and 6.97% respectively. The qualitative phytochemical test of the methanolic extracts showed the presence of carbohydrates, steroids, alkaloids, terpenoids, fatty acids, flavonoids and glycosides. The toxicity study showed that all the extracts tested were safe at all dose levels tested. By the result of the study it was concluded that, stem bark of Butea monosperma can be considered as a potential source for developing an effective and safe herbal contraceptive formulation that could deliver action comparable to the currently available hormonal contraceptive formulations or spermicidal preparations, which are effective but have several limitations.

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