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Determination and Identification of Loratadine by Various Analytical Methods Using UV-Visible, FT-IR, and HPLC Chromatographic Techniques

Mohammad Aftab Mansury, Rajesh Kumar Jatav, Rakesh K. Jatav

Abstract


Loratadine, histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria Administration of Loratadine through oral route is a challenge in children, who have not yet learned to swallow tablets. In the present study pharmaceutical and analytical investigation carried out proceeding and supporting formulation development efforts of the dosage form of the drug substance. Loratadine is sparingly soluble in water but freely soluble in the pH of 1.2 to 2.0. The Pka of Loratadine is 4.3. It is extensively absorbed from the gastric pH. A reduction in gastric transit time may cause the drug to move into the alkaline pH of the intestine. standard curve of Loratadine is prepared in 0.1 N HCl absorbance measured at λmax of 280 nm. Standard curve was plotted between conc. (μg/ml) on x-axis and absorbance on y-axis. Various spectroscopic methods are used for the identification and analysis of Loratadine using HPLC, FT-IR and other spectroscopic techniques. Results shows in graph in compare with reference standard to sample drug.

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