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EFFECT OF A NOVEL SYNTHETIC BENZIMIDAZOLE DERIVATIVE ON ULCER FORMATION AND GASTRIC ACID RELEASE IN RATS

A. Rama Narsimha Reddy, P. Priyanka, Syed Abdul Naveed, T. Sunder Rajan

Abstract


The aim of the present study is to evaluate the effect of a novel selected synthetic benzimidazole derivative i.e. 2-Imino-N(2-mercapto-1h-benzo[d]imidazol-5-yl)-2H-chromene-3-carboxamide on ulcer formation and gastric acid release in rats. Pylorus ligation method was used to induce gstric ulcers in rats. Five groups of male wistar albino rats were used in the study. Group 1 and group 2 served as normal control group and ulcer control group, whereas group 3 (20mg/kg of test compound) and group 4 (40mg/kg of test compound) serves as test groups and group 5(20mg/kg of Omeprazole) served as standard control group respectively. Before treatment with test and standard drugs ulcer was induced by tight ligation of pylorus portion of stomach. Immediately after pylorus ligation, test and standard drugs were administered. After 19 hours, the rats were sacrificed and ulcer index, and percentage protection was determined. The stomach contents were analyzed for gastric acid volume, gastric acid pH and gastric acidity. Treatment with both Omeprazole and test compound showed a significant reduction (p< 0.01) in ulcer index, gastric acidity and increase in gastric acid pH. Treatment with test compound showed the significant protection against the ulcers induced by pylorus ligation. Histopathological studies revealed that ulcer control group exhibited severe damage of gastric mucosa compared to rats treated with test compound and omeprazole which showed gastric mucosal protection by test compound. The present findings suggest that test compound promotes ulcer protection as ascertained grossly and histologically as compared to the ulcer control group. In conclusion test compound possesses anti ulcer property which might be due to its antisecretory activity.

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