Ziziphus xylopyrus Willd. (Z. xylopyrus) is reported for widely use in diarrhoea, chest pain, analgesic, anti-inflammatory and healing of wounds in folk medicine. The aim of our study is to determine the antipyretic and antistress activity of hydroalcoholic extract of Z. xylopyrus fruits. The anti pyretic activity evaluated by milk induced pyrexia and antistress activity by swimming endurance test, writhing test and anoxic tolerance test in Swiss Albino rats. The extract administered orally at different dosages (100 mg/kg and 200 mg/kilogram). The potential of hydroalcoholic extract of fruits at 200 mg/kg dose in both the activity was extremely significant and equivalent to standard. Results obtained from the present work, it can be inferred that the extract of Z. xylopyrus fruits contributing to the stated activities.